University of Limerick Research Repository

Recent Submissions

  • PublicationOpen Access
    Mixed Reality for People Living With Parkinson’s Disease: Findings from a World Café Event
    (University of Limerick, 2025-06-16) Senter, Morgan; Cunneen, Mártín; Tennent, Paul; Ní Bhriain, Orfhlaith; Cassidy, Irene; Cassidy, Irene; De Vries, Nienke M.; Coote, Susan; Volpe, Daniele; Brandt, Sami S.; Morris, Meg E.; Desai, Shital; Yang, Michael Ying; Clifford, Amanda M.
    This information booklet describes findings from a World Café event on mixed reality for people living with Parkinson's disease. The event, led by the MotiVerseP Working Group, was hosted at the University of Limerick on June 16, 2025. People living with Parkinson's disease, their family members and caregivers, and healthcare professionals participated in several small roundtable discussions. Conversations focused on identifying opportunities, challenges, and ethical challenges associated with mixed reality for people with Parkinson's disease. This booklet was created after the event to share with research participants. It is also a useful information resource for researchers, healthcare professionals, or members of the public interested in learning more about stakeholders' opinions of mixed reality for people living with Parkinson's.
  • PublicationOpen Access
    Extrinsic trust as a contractual framework for accountable AI in health care: viewpoint
    (JMIR Publications, 2026-03-05) Kelly, Anthony
    Artificial intelligence (AI) promises efficiency and equity in health care. However, adoption remains fragmented due to weak foundations of trust. This Viewpoint highlights the gap between intrinsic trust, based on interpretability, and extrinsic trust, based on functional validation. We propose a contractual framework between AI systems and users defined by 3 promises: reliability, scope and equity, and shift and uncertainty. Illustrated through a vignette, we show how health systems can operationalize these promises through structured evidence and governance, translating trustworthy AI into accountable clinical deployment.
  • PublicationOpen Access
    Enhancing sperm resilience: protective effects of ectoine on post-thaw bovine sperm quality under environmental stress conditions
    (Oxford University Press, 2026-02-11) Weldon, Kaitlyn; Fair, Sean
    Ectoine is a small, amino acid-derived osmolyte produced by extremophilic bacteria that acts as a compatible solute, protecting cellular macromolecules and structures from extreme environmental stress without disrupting essential cellular functions. The aim of this study was to evaluate the biocompatibility of ectoine with bull sperm and to assess the potential of ectoine to enhance the resilience of sperm under varying stress conditions. Thawed bovine sperm in the presence (0.5, 5, and 50 mM) or absence (control; 0 mM) of ectoine were subjected to a biocompatibility test (37 °C for 6 h; n = 8 bulls), heat stress (39 or 42 °C for 6 h; n = 8 bulls) or osmotic stress (150 or 400 mOsm for 15 min; n = 12 bulls), whereby motility and kinematic parameters, as well as viability, acrosome integrity, and membrane fluidity by flow cytometry were assessed. Sperm motility in cervicovaginal mucus (37 °C for 3 h; n = 6 bulls) was also assessed. All results are reported as mean ± SEM. Ectoine displayed a non-toxic effect across all motility and functional parameters (viability, acrosome integrity, and membrane fluidity). Nonetheless, a reduction in kinematic parameters, including straight line velocity (VSL), average path velocity (VAP) and straightness (STR) was observed at 50 mM ectoine (P < 0.05). Under heat stress at 39 and 42 °C, ectoine concentrations of 0.5 and 5 mM maintained motility and viability, comparable to controls across all time points (P > 0.05). In hypoosmotic conditions (150 mOsm), individual bulls displayed different degrees of osmotic resistance. In those bulls with poor osmotic resistance (n = 4), ectoine (0.5 and 5 mM) maintained sperm viability similar to the 0 mM control (P > 0.05). However, the viability of sperm incubated with 50 mM solute was 2-fold higher relative to the control (P < 0.001). In hyperosmotic conditions, addition of ectoine to sperm prior to exposure did not affect the total motility or viability compared to the no ectoine treatment (P > 0.05). When sperm were incubated in cervicovaginal mucus, there was an effect of ectoine treatment. Sperm treated with 50 mM ectoine exhibited higher motility throughout incubation compared to the control (0 mM) (P < 0.05). In conclusion, these findings establish ectoine as a promising candidate for improving sperm resilience and warrants further studies to assess additional protective effects of ectoine.
  • PublicationOpen Access
    On-demand dynamic charging pricing strategy for Electric Vehicles
    (Elsevier, 2026-03-01) Hussain, Adil; Lu, Qing-Chang; Qureshi, Kashif Naseer
    Electric Vehicles (EVs) charging pricing plays an important role in reducing the charging demand during peak hours and increasing Charging Station Operator (CSO) profits. However, the existing studies have overlooked the charging pile availability and the current Charging Stations (CS) occupancy. This study proposes a novel on-demand dynamic pricing strategy considering limited charging spaces and CS occupancy using the low and high occupancy thresholds, with low and high cost adjustments in the charging costs. The idle occupancy at the CSs with a limited number of spaces can reduce the CSO profit; therefore, the idle time penalty is also introduced. The real-world EV charging data of 6 CSs from 3 districts of Jiaxing city, China, is used. The case study also includes analysis of occupancy thresholds, cost adjustments, idle time penalty limits, and penalty costs. The findings show that the proposed strategy, including both algorithms, improved CSO profits across most EV charging sites as compared to Time-of-Use (ToU) pricing. The profits are increased by 8.019% with algorithm 1 and 9.603% with algorithm 2 for the Bus Station location. The Government Agency site achieved a 4.284% and 6.109% increase, while the Shopping Mall also increased by 3.315% and 5.107%, respectively. The Tourist Attraction location also experienced profit rises of 0.657% and 2.710%. Expressway Service District C and Financial Industrial Park showed a slight decrease of −0.237% and −0.299% with Algorithm 1, and improved by 1.824% and 1.442% using Algorithm 2, respectively. The results highlight that algorithm 2 consistently improves profit across all six CS locati
  • PublicationOpen Access
    Attention to principles of training and exercise prescription in systematic reviews of exercise for functional performance in older adults: an umbrella review
    (Springer Nature, 2026-01-16) Morrison, Robert T.; Mannion, Lily; MacDonncha, Ciaran
    Background Exercise interventions are essential for maintaining functional independence in older adults, with systematic reviews guiding evidence-based practice. However, implementing these interventions requires detailed information about exercise parameters, progression strategies, and contextual adaptations that extend beyond basic intervention descriptions. The adequacy of systematic reviews in providing this practice-essential information remains unevaluated. We examined systematic reviews’ attention to exercise training principles, FITT-VP components, and implementation context in interventions for functional performance in community-dwelling older adults. Methods Six databases were searched for systematic reviews of exercise interventions published 2014–2024. Two reviewers independently screened studies and extracted data on FITT-VP components (Frequency, Intensity, Time, Type, Volume, Progression), fundamental exercise principles (specificity, overload, individualisation, reversibility, variation), and implementation context (setting adaptability, equipment, supervision, safety, adherence). Quality was assessed using the JBI critical appraisal tool. Results Twenty five systematic reviews met inclusion criteria. While reporting of frequency (23/25, 92%) and type (19/25, 76%) were well-reported, critical parameters showed deficiencies in terms of complete reporting: intensity (6/25, 24%), time (11/25, 44%), volume (9/25, 36%), and progression (0/25 0%). Exercise principles received minimal attention in terms of specificity (2/25, 8% complete), individualisation (1/25, 4%), and overload (1/25, 4%). Diminishing returns were not discussed. Implementation context showed poorest reporting with equipment requirements (11/25, 44% complete), supervision protocols (2/25, 8%), and safety considerations (0/25, 0% complete). No review (25/25) considered the alignment of component-based interventions with integrated functional assessments. Temporal analysis revealed no improvement between pre-2020 reviews (n = 6, mean 4.2 complete items, 23%) and post-2020 reviews (n = 19, mean 3.4 complete items, 19%). Methodological quality (JBI scores) inversely correlated with reporting completeness (ρ = − 0.379, p = 0.062). Sensitivity analysis excluding four partially eligible reviews confirmed all findings were robust (largest change 5.9%). Conclusions Systematic reviews of exercise interventions for older adults demonstrate incomplete reporting of information necessary for implementation. Substantial gaps exist in progression protocols, training principles, and implementation context. Limited discussion of relationships between intervention approaches and functional assessments may contribute to challenges in translating research to practice. Enhanced reporting standards would benefit the field.