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Publication Open Access Anticoagulant effect and platelet bioactivities of a novel cephalopod byproduct oil(MDPI, 2026-04-23)This study investigates the effects of a novel marine byproduct oil extracted from the cephalopod Nototodarus sloani (Arrow squid) on human platelets and red blood cells (RBCs). The oil was produced using enzyme-assisted extraction under varying pHconditions without further refining. The level of oxidation of the different oils was determined. Hemocompatibility and oxidative effects were evaluated after 24 h of incubation at physiological and fever-like conditions. Hemolysis levels varied with extraction conditions and with the amount of oil in contact with the cells. Oils extracted using 0.5% Alcalase® and 1% ProtamexTM ® at pH 5.9 demonstrated superior hemocompatibility. Intracellular reactive oxygen species (ROS) levels presented a dose-dependent increase, with higher levels observed in oils extracted at a higher pH. Although there was no direct correlation between hemolysis rate, ROS levels and oxidation, the less oxidized oils presented lower ROS formation and better hemocompatibility. Additionally, the oils exhibited a strong anticoagulant effect and low IC50 values against TRAP-6-induced platelet aggregation. These findings highlight the potential of Nototodarus sloani as a source of bioactive compounds, providing initial evidence of potential cardiovascular benefits and resource valorization, underlining the importance of extraction conditions in determining the biological properties of marine byproduct oils.Publication Open Access Recommendations for the inclusion of autistic children in community-based physical activity programmes: A Delphi study(Sage, 2026-05-31)A range of barriers to Physical Activity (PA) participation contribute to autistic children being less physically active than their non-autistic peers. While these barriers have been well documented, further research is needed into methods of overcoming these barriers. This study aimed to create a series of best practice recommendations for the inclusion of autistic children in community-based PA programmes. This was achieved using the Delphi Method involving the opinions of international experts in the area of inclusion of autistic children in PA. Three rounds of questionnaires were distributed to the panel of 22 experts, aiming to reach consensus on a series of topics related to the inclusion of autistic children in community-based PA programmes (consensus ⩾67% agreement). Topics included coaches and volunteers, programme characteristics, and bridging sessions. Sixteen consensus statements were established which were then used to create the ‘STARTS’ recommendations, which centre around: (1) Skill development, (2) Training for coaches/volunteers, (3) Aims for sessions, (4) Resources to improve children’s experiences, (5) Transitioning from bridging programmes to mainstream programmes, and (6) Supports to improve inclusion. The STARTS recommendations will assist clubs/organisations when setting up or modifying community-based PA programmes which include autistic children.Publication Open Access Parametric analysis of thermodynamic and economic performance of high-temperature heat pump using CO 2 /acetone zeotropic mixtures: Effects of condenser pressure drop on system performance(Elsevier, 2026-09-01)Despite the growing industrial demand for high-temperature heat pumps (HTHPs), systematic studies that simultaneously evaluate thermodynamic performance and economic viability of CO 2 -based zeotropic mixtures which includes condenser pressure drop effect remain scarce. The lack of studies comparing pure refrigerants with zeotropic mixtures by accounting condenser pressure drop effects, limits the ability to make informed refrigerant selection decisions. This study presents a comprehensive thermodynamic and economic comparison between pure acetone and CO 2 /acetone zeotropic mixture for HTHPs. A consistent cycle configuration was applied for all fluids, and condenser sizing was iteratively determined. Thermodynamic analysis reveals that introducing CO 2 improves both Coefficient of Performance (COP) and effective COP, with optimal performance observed at 8–10% CO 2 mass fraction at the specified boundary conditions to achieve a lift temperature of 70K. At an evaporator outlet temperature of 140 ◦ C, the COP peaks at 4.8 for 10% CO 2 , compared with 3.1 for pure acetone. Accounting for condenser pressure drop reduces pure acetone COP by 12–16%, whereas mixtures with 6–12% CO 2 experience reductions below 5%. Economic analysis mirrors these trends the 8% CO 2 /92% acetone mixture achieves the lowest levelized cost of heat (0.055 €/kWh), shortest payback (3.02 years), and highest net present value (851.5 k€) outperforming pure acetone. Inclusion of condenser pressure drop raises pure acetone's LCOH by 13.6%, while zeotropic mixtures containing 4 – 8% CO 2 remain below 5%, and mixtures with 8–12% CO 2 show increases under 3%. These findings identify 8–10% CO 2 balances thermodynamic efficiency and economic advantage under specified conditionsPublication Open Access Teachers’ perspectives on curriculum changes at lower secondary-level mathematics: a focus on classroom-based assessments(Routledge Taylor & Francis Group, 2026-05-27)Assessment, as part of the tested curriculum, plays an important role internationally in certifying student achievement in secondary education. Following global trends, a recent reform of Junior Cycle curricula (lower secondary level) in Ireland introduced school-based assessments (SBAs) alongside traditional state examinations. Known locally as Classroom-Based Assessments (CBAs), they are part of a ‘dual assessment’ system, combining centralized examinations with non-certified assessments conducted by teachers. This study examines the perspectives of mathematics teachers towards these changes in their subject. An online survey, using a nonprobability sampling method, collected 196 responses. While certain advantages were identified, including the promotion of independent learning and the incorporation of real-life applications, the findings also reveal persistent concerns among mathematics teachers regarding the introduction of CBAs. Key challenges include the significant amount of class time required, limited student engagement, and the potential to exacerbate existing student inequities. These concerns raise important questions about the ongoing implementation of CBAs in their current format within the Junior Cycle Mathematics Specification (JCMS). The findings are also considered in relation to broader international debates on curriculum and assessment reform, highlighting common challenges and enhancing understanding of how policy initiatives are interpreted, mediated, and contested across educational contexts.Publication Open Access Template-guided sodium intercalation enables phase-pure alkali metal-based ternary chalcogenides nanocrystals(The Royal Society of Chemistry, 2026-05-28)Alkali metal-based ternary chalcogenides are promising materials which remain synthetically underexplored. Here, a template-based strategy enables synthesis of colloidal NaInS2 and NaIn3Se5 nanocrystals. Mechanistic insights reveal sodium intercalation as a predictive route to phase-pure ABZ nanocrystals.
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