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Publication Open Access Climate-Sensitive daylighting design in India: Integrating passive strategies for sustainable building performance(John Wiley & Sons Ltd, 2026-06-17)Daylighting plays a vital role in reducing building energy demand while ensuring visual and occupant comfort across India’s diverse climates. This review synthesizes findings from 31 peer-reviewed studies published between 2015 and 2025 that analyze daylight performance through climate-based simulations, optimisation approaches, and field validation. Evidence across major climatic zones and building typologies reveals consistent design patterns and methodological developments. Moderate window-to-wall ratios of about 16%–20% repeatedly deliver balanced daylight autonomy and glare control, especially when paired with orientation-responsive shading. Courtyard configurations and overall building form were found to strongly influence vertical daylight distribution, with optimized height-to-width ratios enhancing spatial daylight autonomy by up to 93%. Dynamic shading systems and multi-objective optimisation frameworks outperform isolated parametric studies by more effectively resolving daylight, glare, and energy trade-offs, achieving lighting energy savings of roughly 26%. Vegetation layers and surrounding obstructions also affect daylight penetration and glare, though urban-scale modeling remains limited. Although climate-based daylight metrics such as sDA, UDI, and ASE are increasingly adopted, cross-climatic benchmarking, uncertainty analysis, and standardized validation procedures require further development. Emerging human-centric metrics, including vertical illuminance and circadian performance, show promise but are not yet systematically integratedPublication Open Access Effectiveness of manual therapy with pragmatic physiotherapy for rotator cuff-related shoulder pain: a pilot randomized clinical trial(AboutScience Srl., 2026-06-24)Introduction: Physiotherapy for rotator cuff-related shoulder pain (RCRSP) typically includes patient education and exercise prescription, with manual therapy used as an adjunct to exercise. This parallel two-arm non-inferiority pilot trial determined the feasibility of a full randomised clinical trial comparing pragmatic physiotherapy with manual therapy (MT Group) to pragmatic physiotherapy without manual therapy (NoMT Group) for RCRSP, and explored preliminary treatment effects on patient-reported outcomes. Methods: Sixty-eight participants with persistent RCRSP were randomised to MT or NoMT groups, receiving physiotherapy treatments over a 3-month period, with only the MT group receiving manual therapy. Feasibility outcomes were recruitment and retention rates, adherence, and intervention fidelity. Research outcome measures were patient-related outcomes at baseline, 3, and 6-month follow-up. Results: Of 239 volunteers completing the online screening questionnaire, 108 were physically screened, and 70 (65%) were allocated. After two withdrawals, 33 in the MT group and 35 in the NoMT group completed baseline assessment. Retention, adherence, and fidelity exceeded 80% for both groups. Median treatment sessions were 7 for the MT group and 6 for the NoMT group. In the MT group, glenohumeral joint, thoracic spine, and soft tissue mobilisations were commonly used. Delivery of patient education and exercise prescription was similar between groups. QuickDASH between-group mean differences were below the non-inferiority margin. Self-efficacy favoured the MT group at 6-month follow-up. Conclusion: Results support feasibility for a full trial. Strategies to improve participant diversity are required. Definitive outcomes require confirmation in a full trial.Publication Open Access Enhanced recombinant adeno-associated virus (rAAV) biomanufacturing: Design of experiment (DOE) enabled transfection optimization for maximum full capsid yield and robust scale-up(Wiley-VCH GmbH, 2026-05-28)Recombinant adeno-associated virus (rAAV) gene therapies are a promising class of therapeutics. While their production via triple transfection in a single cell line offers flexibility regarding modification of the transgene, it faces significant challenges, particularly regarding predominance of empty capsids, reproducibility of process performance (titre and product quality), and successful scale-up. This study addresses these limitations by employing a two-stage Design of Experiment (DOE) approach to optimize triple transfection for rAAV5 viral vector production. An initial screening design systematically evaluated a comprehensive set of factors for their impact on transfection efficiency, genome titre, capsid titre, and the ratio of full to empty capsids. Four highly influential factors identified during screening were further investigated in a second-stage response surface design. Statistical analysis confirmed that DNA amount, complexation time, FectoVir-AAV volume, and the ratio of pTransgene were the most critical determinants of performance. The optimal conditions were successfully scaled up from 6 well plates to a 50 L Wave reactor. Coupled with the implementation of an alternative harvest strategy, transfection efficiencies, capsid, and genome titre were maintained while there was an increase in % full capsids to 73% at scale demonstrating a viable, robust, and scalable manufacturing strategy for high-quality rAAV5 vectors.Publication Open Access Breakage of a single oil drop in water via acoustic and hydrodynamic cavitation(AIP Publishing, 2025-06-04)Liquid–liquid emulsions find extensive applications across several industrial sectors, including healthcare, personal care, home care, food, and agrochemicals. Acoustic cavitation (AC) and hydrodynamic cavitation (HC) have emerged as viable options for producing such emulsions. Therefore, understanding the droplet–cavity interaction leading to droplet breakup is crucial. Experiments were conducted to understand the interactions between the cavity/cavity cloud and oil droplet. AC was generated using an ultrasonic horn, whereas a snapping mechanism was used for generating HC. The droplet size distribution (DSD) via these two methods was analyzed. Using image processing and autocorrelation analysis, a decay rate ðbÞ was obtained for both cavitation methods. The b is larger, and D90 is smaller for HC than AC. Both cavitation methods resulted in a bimodel droplet distribution. Smaller droplets are created upon interaction with the collapsing cavity, whereas large droplets are due to cavitation-induced turbulent shear. The study improves understanding of the interactions of oil drops suspended in water with cavities generated by AC and HC scenarios. The experimental data also provides a useful basis for developing and validating improved models for simulating cavitation-induced droplet breakage, enabling enhanced applications of cavitation for emulsification in the chemical industries.Publication Open Access Outcome measurement instruments used in the evaluation of key psychological constructs in people with tendinopathy: A scoping review(Elsevier, 2026-08-01)Objective: To identify and describe the pain-related psychological outcome measurement instruments used to measure kinesiophobia, pain beliefs, pain self-efficacy and fear avoidance beliefs in tendinopathy research. Design: Scoping review following the Joanna Briggs Institute Framework and the PRISMA-ScR reporting guideline. Literature search: Seven electronic databases (MEDLINE, PsychINFO, EMBASE, CINAHL, Scopus, Web of Science and Google Scholar) were searched from inception to March 23rd, 2025, for published tendinopathy studies. Study selection criteria: Eligible studies included adults (≥18 years) with a clinical diagnosis of tendinopathy that reported at least one recorded psychological outcome measurement instrument for the constructs of interest. Data synthesis: Data were collated for study characteristics, tendon site (synonyms used), psychological construct, outcome measurement instrument type/version/frequency, cutoff scores and pre-post intervention scores. Results: Ninety-three studies (n = 7041 participants) were included: 25 RCTs, 55 observational studies and 13 other designs. Kinesiophobia was the most frequently assessed construct (69%) using various versions of the Tampa Scale of Kinesiophobia. Pain self-efficacy (21.5%) was primarily measured with the Pain Self Efficacy Questionnaire; Fear avoidance beliefs (19.4%) with the Fear Avoidance Beliefs Questionnaire and pain beliefs (1.1%) with unvalidated instruments. Baseline kinesiophobia and fear-avoidance scores generally indicated low to moderate severity with minimal pre-post intervention change scores. Conclusion: Considerable heterogeneity and conceptual ambiguity were identified in assessing psychological constructs in tendinopathy. These findings highlight the need for greater standardisation and consensus in outcome measurement to enhance consistency, interpretability, and clinical applicability in tendinopathy research and practice.
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