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Adipocyte-epithelial interactions and crohn's disease - an emerging drug target

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journal contribution
posted on 2017-11-08, 09:58 authored by Calvin J. Coffey, Miranda G. Kiernan
Crohn's disease is hallmarked by mesenteric abnormalities including thickening, shortening and extension ofmesenteric fat over the intestinal surface (“fat wrapping” or “creeping fat”) (Coffey et al., 2016; Peyrin-Biroulet et al., 2007; Sheehan et al., 1992; Crohn et al., 1932). Mesenteric and submucosal mesenchymal abnormalities overlap in histological appearance and both inflammatory fronts meet to generate transmural inflammation (Coffey and O'leary, 2016).

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Publication

EBioMedicine;23, pp. 193-94

Publisher

Elsevier

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peer-reviewed

Language

English

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