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Anticancer potential of dendritic poly(aryl ether) substituted polypyridyl ligands based ruthenium(II)- coordination entities
1. Synthesis and characterizations 1.1. Synthesis of Ruthenium(II)-cored metallodendrimers The synthesis of [Ru(bpy)2Gn-bpy]Cl2 complexes RuG0, RuG1 and RuG2 involves the reaction of [Ru(bpy)2Cl2.2H2O]Cl2 and corresponding Gn-bpy ligands under inert atmosphere. The obtained residue was purified by column chromatography to obtain the complexes [Ru(bpy)2G0-bpy]Cl2 (RuG0), [Ru(bpy)2G1-bpy]Cl2 (RuG1) and [Ru(bpy)2G2-bpy]Cl2 (RuG2). 1.1.2. Synthesis of 4,4'-bis[3'',5''-bis(2-(tert-butoxy)-2-oxoethoxy) benzyloxy]2,2'- bipyridine-bis(2,2’-bipyridine) Ruthenium (II) (RuG0) The complex RuG0 was obtained by the reaction of [Ru(bpy)2Cl2] and G0-bpy in 1:1.05 ratio. The crude product was purified by column chromatography (SiO2/dichloromethane: methanol 20:1 mixture); the product was obtained as red solid, Yield 70%.
Funding
Career Development Fellowships in the National Technology Centre Programme
European Commission
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Publication
ACS Applied Bio Materials 6 (10), pp. 4226-4239Publisher
ACSOther Funding information
Science and Engineering Research Board, Department of Science and Technology (DST-SERB) for the funding under the Young Scientist Scheme (CS155/2013)Rights
This is the author’s version of a work that was accepted for publication in . ACS Applied Bio Materials 2023 6 (10), pp. 4226-4239 Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in ACS Applied Biomaterials Publication 6,10 https://doi.org/10.1021/acsabm.3c00452Also affiliated with
- Bernal Institute
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- Chemical Sciences
