University of Limerick
Browse
Morrissey_2020_Covert.pdf (1.6 MB)

Covert cognition in disorders of consciousness: A meta-analysis

Download (1.6 MB)
journal contribution
posted on 2020-12-09, 09:30 authored by Caroline Schnakers, Michaela Hirsch, Enrique Noé, Roberto Llorens, Nicolas Lejeune, Vigneswaran Veeramuthu, Sabrina De Marco, Athena Demertzi, Catherine Duclos, Ann-Marie Morrissey, Camille Chatelle, Anna Estraneo
Covert cognition in patients with disorders of consciousness represents a real diagnostic conundrum for clinicians. In this meta-analysis, our main objective was to identify clinical and demographic variables that are more likely to be associated with responding to an active paradigm. Among 2018 citations found on PubMed, 60 observational studies were found relevant. Based on the QUADAS-2, 49 studies were considered. Data from 25 publications were extracted and included in the meta-analysis. Most of these studies used electrophysiology as well as counting tasks or mental imagery. According to our statistical analysis, patients clinically diagnosed as being in a vegetative state and in a minimally conscious state minus (MCS−) show similar likelihood in responding to active paradigm and responders are most likely suffering from a traumatic brain injury. In the future, multi-centric studies should be performed in order to increase sample size, with similar methodologies and include structural and functional neuroimaging in order to identify cerebral markers related to such a challenging diagnosis.

History

Publication

Brain Sciences;

Publisher

MDPI

Note

peer-reviewed

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC