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ECM-based materials in cardiovascular applications: inherent healing potential and augmentation of native regenerative processes

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posted on 2022-08-24, 13:32 authored by ANNA PITERINAANNA PITERINA, Aidan J. Cloonan, Claire L. Meaney, Laura M. Davis, Anthony Callanan, MICHAEL WALSHMICHAEL WALSH, Timothy M. McGloughlin
The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.

Funding

A new method for transforming data to normality with application to density estimation

National Research Foundation

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History

Publication

International Journal of Molecular Sciences;10 (10), pp. 4375-4417

Publisher

MDPIAG

Note

peer-reviewed

Other Funding information

EI, IRCSET

Language

English

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