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Effect of impeller design on homogeneity, size and strength of pharmaceutical granules produced by high-shear wet granulation

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posted on 2019-05-24, 14:36 authored by Chirangano Mangwandi, Zakaria Mirza, Jiang T. Liu, Yoann Glocheux
Small mixer impeller design is not tailored for granulation because impellers are intended for a wide range of processes. The aim of this research was to evaluate the performances of several impellers to provide guidance on the selection and design for the purposes of granulation. Lactose granules were produced using wet granulation with water as a binder. A Kenwood KM070 mixer was used as a standard apparatus and five impeller designs with different shapes and surface areas were used. The efficacy of granulate formation was measured by adding an optically sensitive tracer to determine variations in active ingredient content across random samples of granules from the same size classes. It was found that impeller design influenced the homogeneity of the granules and therefore can affect final product performance. The variation in active ingredient content across granules of differing size was also investigated. The results show that small granules were more potent than larger granules.

History

Publication

Particuology;23, pp. 31-39

Publisher

Elsevier

Note

peer-reviewed

Rights

This is the author’s version of a work that was accepted for publication in Particuology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Particuology, 2015, 23, pp. 31-39, https://doi.org/10.1016/j.partic.2014.12.009

Language

English

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