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Enzymatic biofuel cells for self-powered, controlled drug release

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posted on 2024-10-10, 10:52 authored by Xinxin Xiao, Frank Mc GourtyFrank Mc Gourty, Edmond MagnerEdmond Magner

Self-powered drug-delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources are of significant interest for use in clinical applications. Osmium redox polymer-mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an additional CP–drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU), and 4′,6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug-release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug-release system that may be used in implantable devices.

Funding

Biofuel Cells : From fundamentals to applications of bioelectrochemistry

European Commission

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History

Publication

Journal of the American Chemical Society, 2020, 142, (26), pp. 11602–11609

Publisher

American Chemical Society

Other Funding information

This work was financially supported by the European Commission (FP7-PEOPLE-2013-ITN 607793 “Bioenergy”). X.X. acknowledges an IRC Postgraduate Scholarship (GOIPG/2014/659) and a H. C. Øersted COFUND fellowship. Funding from the Programme for Research in Third-Level Institutions (PRTLI) cycles 4 and 5 is acknowledged. K.D.M. acknowledges a Health Research Institute Seed Funding Award from the University of Limerick (UL). We thank Prof. Dónal Leech and Dr. Peter Ó Conghaile from the National University of Ireland Galway for providing osmium redox polymers. Prof. Jens Ulstrup is acknowledged for proof reading.

Rights

© 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal Title, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.0c05749

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  • Bernal Institute

Sustainable development goals

  • (7) Affordable and Clean Energy

Department or School

  • Chemical Sciences

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