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Enzymatic biofuel cells for self-powered, controlled drug release.

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journal contribution
posted on 2020-06-24, 08:11 authored by Xinxin Xiao, Kieran Denis McGourty, EDMOND MAGNEREDMOND MAGNER
Self-powered drug delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources, are of significant interest for use in clinical applications. Osmium redox polymer mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an addi-tional CP-drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU) and 4',6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug release system that may be used in implantable devices.

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History

Publication

Journal of the American Chemical Society;142 (26), pp. 11602-11609

Publisher

American Chemical Society

Note

peer-reviewed

Other Funding information

ERC, IRC, European Union (EU)

Rights

© 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.0c05749

Language

English

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