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Experimental evaluation of a patient specific Brachio-Cephalic Arterio Venous Fistula (AVF): Velocity flow conditions under steady and pulsatile waveforms

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posted on 2022-11-10, 10:09 authored by Neda Alam, MICHAEL WALSHMICHAEL WALSH, DAVID NEWPORTDAVID NEWPORT

 Arterio-Venous Fistulas (AVF) are the most popular form of vascular access used for hemodialysis. However they  continue to present complications leading to early and late failure. To understand the reasons for failure, it is  necessary to analyze the hemodynamics involved. Wall shear stress (WSS) is commonly studied in AVFs as it often  relates to cardiovascular disease, although there is dispute over whether high or low WSS is detrimental to AVF  patency. The goal of this paper is to investigate velocity flow conditions in a rigid, patient-specific brachio-ce?phalic AVF model in both steady flow (Re = 1817) and patient-specific pulsatile flow (Reav = 1817, Remax = 2233). Particle Image Velocimetry (PIV) measurements were performed at the anastomosis to capture the com?plex 3D-3C flow present. The results from this study found regions of recirculation and high velocity fluctuations  in the distal artery and proximal vein, and flow impingement at the anastomosis toe. Steady and pulsatile flow  demonstrated similar flow features, possibly owed to the low pulsatility index. In addition, the recirculation zone  did not vary along the waveform. The directional variability was seen to be the highest at the regions of  recirculation and flow impingement suggesting regions of high transWSS while the coefficient of variation was  greatest at the walls and in areas of flow separation indicating high temporal wall shear stress.  

Funding

Development of hemodynamic solutions in Renal Dialysis Venous Access Failure

European Commission

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Publication

Medical Engineering and Physics 106, 103834

Publisher

Elsevier

Also affiliated with

  • Bernal Institute
  • Health Research Institute (HRI)

Department or School

  • School of Engineering

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