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Growth kinetics of nuclei formed from different binders and powders in vertical cylindrical mixing devices

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journal contribution
posted on 2018-03-29, 15:16 authored by Yasmine N. Baghdadi, Rushab K. Shah, Ahmad B. Albadarin, Chirangano Mangwandi
Granulation is the process of forming large aggregates from fine particles using a high shear mixer. This method is used in several industries from pharmaceuticals to chemical and fertilizer production. This research will study the effect of four process variables: speed of mixer rotation in the range 100–200 rpm, powder bed mass (25–40 g), mass of the initial nucleus (0.6–2 g), and binder viscosity (water, carboxymethyl cellulose (CMC) solutions with concentrations in the range 0.5–20 g/L) on single nuclei growth kinetics in low mixing devices. The powders under study were: lactose, tea, sugar, starch, and limestone. The results show the initial size of nuclei, the initial mass of the powder bed and binder viscosity and speed of rotation all influence the rate of nuclei growth. Analysis of the stokes deformation number of the nuclei show that growth rate of the nuclei decreases as the deformation number increases whilst the percentage gain in mass of the nuclei increases with increasing deformation number. The binder viscosity was shown to have the biggest influence of the growth rate of the nuclei. Results show that difference in powder density also has an effect on the growth kinetics of nuclei. The initial position of nuclei was also shown to influence the nuclei growth rate; the closer the starting position of the nuclei to the wall of the vessel the slower the growth rate.



Chemical Engineering Research and Design;132, pp. 1070-1081






This is the author’s version of a work that was accepted for publication in Chemical Engineering Research and Design. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Engineering Research and Design, 2018, 132, pp. 1070-1081,



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