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Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

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posted on 2021-10-20, 06:42 authored by Ebrahim Rajab, Michael B. Keogh, Ashang L. Laiva, Fatima Al Hannan, Maryam Fateel, Fatema Abdulwahab, Fatema Al Madhoob, Bassam AlHamer, Samar Y. Ghazzal, Abdulla Dawaishan, Sadiq Mahdi, Abdulrahman Qareeballa, Sayed M. Almosawi, Faisal Falamarzi, Khalifa ElmusharafKhalifa Elmusharaf, Amer Kamal
The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.

Funding

OUR GOAL IS TO IDENTIFY AND ASSESS NEW RISKS IMPOSED BY SMALL UNMANNED AIRCRAFT SYSTEMS (SUAS) OPERATING IN THE NATIONAL AIRSPACE SYSTEM (NAS). FAILURES AND ASSOCIATED HAZARDS UNIQUE TO A REPRESENTATIVE CLASS OF SUAS WILL BE IDENTIFIED AND CLASSIFIED. WE

National Aeronautics and Space Administration

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History

Publication

Journal of Functional Foods;87, 104757

Publisher

Elsevier

Note

peer-reviewed

Other Funding information

Arabian Gulf University, Royal College of Surgeons in Ireland, Medical University Bahrain

Language

English

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