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Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study

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posted on 2020-04-06, 10:30 authored by Patrıcia Merly Martinelli, Isabel Cristina Esposito Sorpreso, Rodrigo Daminello Raimundo, Osvaldo de Souza Leal Junior, Juliana Zangirolami-Raimundo, Marcos Venicius Malveira de Lima, Andres Perez-Riera, Valdelias Xavier Pereira, Khalifa Elmusharaf, Vitor Engracia Valenti, Luiz Carlos de Abreu
Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen’s d = 0.53, pNN50: p = 0.0004, Cohen’s d = 0.68; HF: p = 0.024, Cohen’s d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.

History

Publication

PLoS ONE;0225866

Publisher

Public Library of Science

Note

peer-reviewed

Other Funding information

National Council for Scientific and Technological Development-CNPq

Language

English

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