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Hydrothermal processing of Sarcopeltis skottsbergii and study of the potential of its carrageenan for tissue engineering

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journal contribution
posted on 2024-04-17, 13:58 authored by Milena Álvarez-Viñas, Fernanda ZamboniFernanda Zamboni, María Dolores Torres, Maurice CollinsMaurice Collins, Herminia Domínguez

The red macroalga Sarcopeltis skottsbergii was subjected to hydrothermal processing to maximize the solubilization and recovery of carrageenan. Once isolated by ethanol precipitation, the carrageenan was further chemically (oligosaccharides composition), and structurally (TGA/DTG, DSC, HPSEC, FTIR-ATR, 1H NMR, SEM, etc.) characterized, as well as employed as source for the synthesis of hydrogels. The rheological properties of the carrageenan showed promising results as biopolymer for food applications due to the high molecular weight (500 kDa) presenting higher cell viability than 70 %. The evaluation of immune activation using ELISA test reflected a lower inflammatory response for concentrations of 0.025 % of carrageenan. Conversely, the cell viability of the synthesized hydrogels did not surpass 50 %. This work represents a considerable step forward to obtain a biopolymer from natural sources and a thorough study of their chemical, structural and biological properties.



International Journal of Biological Macromolecules, 2024, 266 (2)131456



Other Funding information

Authors thank the financial support to the Ministry of Science, Innovation and Universities of Spain (RTI2018-096376-B-I00), and to the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019–2022 and ED431C 2018/54-GRC) and the European Union (European Regional Development Fund - ERDF) - (Ref. ED431G2019/06). M.A.V. thanks for her predoctoral FPI grant (PRE2019-090567) to the Ministry of Science, Innovation and Universities (Spain). M.D.T. acknowledges for her postdoctoral grant (RYC2018-024454-I) to the Ministry of Science, Innovation and Universities (Spain) and for the funding support (ED431F 2020/01) to Xunta de Galicia,

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