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Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

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posted on 2018-05-14, 14:34 authored by Hrvoje Augustin, Kieran Denis McGourty, Marcus J. Allen, Jennifer Adcott, Chi Tung Wong, Emmanuel Boucrot, Linda Partridge
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.

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Publication

Neurobiology of Aging;66, pp. 149-157

Publisher

Elsevier

Note

peer-reviewed

Other Funding information

Wellcome Trust

Language

English

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