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In vitro antioxidant and immunomodulatory activity of transglutaminase-treated sodium caseinate hydrolysates
journal contribution
posted on 2017-12-07, 10:05 authored by María M. Cermeño Aínsa, Richard J. Fitzgerald, Nora M. O'BrienSodium caseinate (NaCN) was incubated prior to and after hydrolysis with a microbial transglutaminase (TGase) and hydrolysed with Prolyve 1000. The resultant hydrolysates were tested for their immunomodulatory and antioxidant activity. TGase-treated hydrolysates significantly reduced (p 0.05) differences were found between the TGase-treated and non-TGase-treated samples. In the presence of hydrogen peroxide, the non-TGase-treated sample exhibited the highest DNA protective effect in U937 cells. These findings suggest that NaCN derived hydrolysates with and without treatment with TGase may exert specific antioxidant, genoprotective and anti-inflammatory effects. (C) 2016 Elsevier Ltd. All rights reserved.
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International Dairy Journal;63, pp. 107-114Publisher
ElsevierNote
peer-reviewedOther Funding information
Department of Agriculture, Food and the MarineRights
This is the author’s version of a work that was accepted for publication in the International Dairy Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the International Dairy Journal, 2016, 63, pp. 107-114, https://doi.org/10.1016/j.idairyj.2016.08.007Language
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