Introduction: Hyperemesis gravidarum (HG) is vomiting and/or nausea in pregnancy
causes dehydration, electrolytes imbalance, weight loss and further serious organs
dysfunction. Methods: This was a descriptive, prospective, cross-sectional hospital
based total coverage analytic study, which was conducted from November 2013
to May 2014 at Omdurman New Hospital (ONH) for Obstetrics & Gynecology, Khartoum-
Sudan. Results: HG prevalence is 13% of complicated pregnancy of ONH admission.
Acetonurea is reported in all cases with significant association between acetonurea
and smoking (P value = 0.005). A significant association between Hemoglobulin
level and the readmission the (P value = 0.01) was reported. One maternal
death is reported from severe hypoglycemia and liver impairment. Conclusion:
Hyperemesis gravidarum has serious maternal morbidity with social negative impacts
and significant financial burden on the health services.