University of Limerick
Browse
Murphy_2014_medication.pdf (460.55 kB)

Medication monitoring in a nurse-led respiratory outpatient clinic: pragmatic randomised trial of the West Wales Adverse Drug Reaction Profile.

Download (460.55 kB)
journal contribution
posted on 2016-06-22, 11:04 authored by Marie E. Gabe, Fiona A. Murphy, Gwyneth A. Davies, Ian T. Russell, Susan Jordan
Objective: To assess the clinical effect of medication monitoring using the West Wales Adverse Drug Reaction (ADR) Profile for Respiratory Medicine. Design: Single-site parallel-arm pragmatic trial using stratified randomisation. Setting: Nurse-led respiratory outpatient clinic in general hospital in South Wales. Participants: 54 patients with chronic respiratory disease receiving bronchodilators, corticosteroids or leukotriene receptor antagonists. Intervention: Following initial observation of usual nursing care, we allocated participants at random to receive at follow up: either the West Wales ADR Profile for Respiratory Medicine in addition to usual care (‘intervention arm’ with 26 participants); or usual care alone (‘control arm’ with 28 participants). Main Outcome Measures: Problems reported and actions taken. Results: We followed up all randomised participants, and analysed data in accordance with treatment allocated. The increase in numbers of problems per participant identified at follow up was significantly higher in the intervention arm, where the median increase was 20.5 [inter-quartile range (IQR) 13–26], while that in the control arm was 21 [23 to +2] [Mann-Whitney U test: z = 6.28, p,0.001]. The increase in numbers of actions per participant taken at follow up was also significantly higher in the intervention arm, where the median increase was 2.5 [1–4] while that in the control arm was 0 [2 1.75 to +1] [Mann-Whitney U test: z = 4.40, p,0.001]. Conclusion: When added to usual nursing care, the West Wales ADR Profile identified more problems and prompted more nursing actions. Our ADR Profile warrants further investigation as a strategy to optimise medication management.

History

Publication

PLoS ONE;9 (5) e96682

Publisher

Public Library of Science

Note

peer-reviewed

Other Funding information

Research Capacity Building Collaboration (RCBC) Wales

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC