University of Limerick
Browse
Collins_2018_MitoQ.pdf (33.8 MB)

MitoQ loaded chitosan-hyaluronan composite membranes for wound healing

Download (33.8 MB)
journal contribution
posted on 2018-05-11, 14:08 authored by M. Tamer Tamer, Maurice N. Collins, Katarina Valachová, Mohamed A. Hassan, Ahmed M. Omer, Mohamed S. Mohy-Eldin, Karol Švík, Rastislav Jurčík, L’ubomír Ondruška, Csaba Biró, Ahmad B. Albadarin, Ladislav Šoltés
Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant—MitoQ—was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes.

History

Publication

Materials;11: 569

Publisher

MDPI

Note

peer-reviewed

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC