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NUIG4: A biocompatible pcu metal–organic framework with an exceptional doxorubicin encapsulation capacity†

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posted on 2022-12-13, 09:56 authored by Ahmed Ahmed, Constantinos G. Efthymiou, Rana SaniiRana Sanii, Ewa Patyk-Kazmierczak, Amir M. Alsharabasy, Meghan Winterlich, Naveen KumarNaveen Kumar, Debobroto Sensharma, Wenming Tong, Sarah GuerinSarah Guerin, Pau Farras, SARAH HUDSONSARAH HUDSON, DAMIEN THOMPSONDAMIEN THOMPSON, MICHAEL ZAWOROTKOMICHAEL ZAWOROTKO, Anastasios J. Tasiopoulos, Constantina Papatriantafyllopoulou
Metal–organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4- carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic p–p stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g 1 and high selectivity of 2.75 for C2H2 over CO2

Funding

Creation of physico-chemical bases of synthesis and study of properties of nanostructured orthophosphates of rare-earth elements for creation of high-temperature ceramics on their basis

Russian Foundation for Basic Research

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History

Publication

Journal of Materials Chemistry B;

Publisher

The Royal Society of Chemistry

Note

peer-reviewed

Other Funding information

SFI, Irish Centre for High-End Computing (ICHEC)

Language

English

Also affiliated with

  • Bernal Institute

Department or School

  • Chemical Sciences
  • Physics

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