University of Limerick
Browse
Albadarin_2019_Particle.pdf (1.82 MB)

Particle engineering of excipients: a mechanistic investigation into the compaction properties of lignin and [co]-spray dried lignin

Download (1.82 MB)
journal contribution
posted on 2019-04-24, 13:55 authored by Samuel Solomon, Ahmad Ziaee, Laura Giraudeau, Emmet J. O'Reilly, Gavin M. Walker, Ahmad B. Albadarin
In this work, lignin was spray dried with sodium lauryl sulphate (SLS) in order to improve the compaction properties of lignin. Bulk level and physicochemical properties of spray dried formulations were measured and compared to as-received lignin and lactose which was used as a reference excipient. Single component tablets from individual powders were prepared and the mechanical properties of these powders were investigated by analysing force–displacement curves recorded during tableting, using a series of compaction equations. Moreover, the performance of these excipients in binary blends containing an active pharmaceutical ingredient (API) was investigated. A positive effect of SLS on the mechanical properties and bulk level properties of the spray dried formulations was observed. Spray dried formulations containing SLS showed superior flow properties to pure spray dried lignin while retaining similar particle size distributions. Spray dried formulations containing up to 10 w/w% SLS also showed superior compactibility in binary blends to as-received materials at porosity levels relevant for immediate release tablets. This study highlights the importance of understanding the compaction mechanics of single component powders as a means of predicting their behaviour in multi-component blends.

History

Publication

International Journal of Pharmaceutics;563, pp.237-248

Publisher

Elsevier

Note

peer-reviewed

Other Funding information

SFI

Rights

This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 2019, 563, pp. 237-248, https://doi.org/10.1016/j.ijpharm.2019.03.061

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC