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Patellofemoral joint geometry and osteoarthritis features 3–10 years after knee injury compared with uninjured knees

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posted on 2024-05-09, 14:45 authored by Erin M Macri, Jackie L Whittaker, Clodagh ToomeyClodagh Toomey, Jacob L Jaremko, Jean-Michel Galarneau, Janet L Ronsky, Gregor Kuntze, Carolyn A. Emery


In this cross‐sectional study, we compared patellofemoral geometry in individuals with a youth‐sport‐related intra‐articular knee injury to uninjured individuals, and the association between patellofemoral geometry and magnetic resonance imaging (MRI)‐defined osteoarthritis (OA) features. In the Youth Prevention of Early OA (PrE‐OA) cohort, we assessed 10 patellofemoral geometry measures in individuals 3–10 years following injury compared with uninjured individuals of similar age, sex, and sport, using mixed effects linear regression. We also dichotomized geometry to identify extreme (>1.96 standard deviations) features and assessed likelihood of having extreme values using Poisson regression. Finally, we evaluated the associations between patellofemoral geometry with MRI‐defined OA features using restricted cubic spline regression. Mean patellofemoral geometry did not differ substantially between groups. However, compared with uninjured individuals, injured individuals were more likely to have extremely large sulcus angle prevalence ratio [PR] 3.9 [95% confidence interval, CI: 2.3, 6.6]), and shallow lateral trochlear inclination (PR 4.3 (1.1, 17.9)) and trochlear depth (PR 5.3 (1.6, 17.4)). In both groups, high bisect offset (PR 1.7 [1.3, 2.1]) and sulcus angle (PR 4.0 [2.3, 7.0]) were associated with cartilage lesion, and most geometry measures were associated with at least one structural feature, especially cartilage lesions and osteophytes. We observed no interaction between geometry and injury. Certain patellofemoral geometry features are correlated with higher prevalence of structural lesions compared with injury alone, 3–10 years following knee injury. Hypotheses generated in this study, once further evaluated, could contribute to identifying higher‐risk individuals who may benefit from targeted treatment aimed at preventing posttraumatic OA.

History

Publication

Journal of Orthopaedic Research, 2024, 42, pp. 78-89

Publisher

Wiley and Sons Ltd

Other Funding information

Funding information International Olympic Committee Research Centre; Michael Smith Health Research BC; Arthritis Society; Government of Canada >Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Alberta Innovates Health Solutions

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  • Health Research Institute (HRI)

Sustainable development goals

  • (3) Good Health and Well-being

Department or School

  • Allied Health

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