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Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency

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posted on 2025-01-30, 09:08 authored by Anna Błażewicz, Julia Wojnicka, Andreas GrabruckerAndreas Grabrucker, Piotr Sosnowski, Alicja Trzpil, Anna Kozub-Pędrak, Klaudia Szałaj, Agnieszka Szmagara, Ewelina Grywalska, Katarzyna Skórzyńska-Dziduszko

The present preliminary study aimed to provide a targeted lipidomic analysis of Hashimoto (HT) and non-HT patients with well-controlled hypothyroidism as well as in healthy adults, and is the first to demonstrate the association of several components of the human lipidome with hypothyroidism in relation to the total plasma selenium content.All the patients and age-, sex-, and BMI-matched healthy controls met the very strict qualification criteria. Se levels were analyzed by ICP-MS, and lipidome studies were conducted usingTQ-LC/MS.The 40 acylcarnitines, 90 glycerophospholipids, and 15 sphingomyelins were identified and quantified. PCaaC26:0 and PCaaC40:1 were negatively correlated with Se concentrations. Other lipids that were negatively correlated with Se concentrations but did not present significant differences between the three groups in the Kruskal–WallisANOVA test were PCaaC32:0, PCaeC30:0, PCaeC36:5, SMC18:0, and SM C18:1. In the multiple linear regression analyses, Se levels showed negative relationship, whereas different phosphatidylcholines: PCaaC24:0, PCaaC26:0, PCaeC30:1, PCaeC34:0, PCaeC36:4, PCaeC42:0 were positively associated with the presence of (H). Different lipidome components were identified in healthy and hypothyroid patients regardless of the cause of that condition. Studies on larger populations are needed to determine cause?and-effect relations and the potential mechanisms underlying these associations.

History

Publication

Scientific Reports, 2024, 14, 29140

Publisher

Nature Research

Other Funding information

This work was supported by the Medical University of Lublin (internal grant: DS53/2021–2023/ Anna Błaże?wicz- “Investigation of endocrine disruptors, elemental and lipid profiles in biological fluids and tissues in peo?ple with endocrine and/or metabolic disorders”).

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  • Bernal Institute

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  • Biological Sciences

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