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Protective effects of plant‑derived compounds against traumatic brain injury

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journal contribution
posted on 2024-03-22, 11:30 authored by Danial Khayatan, Seyed Mehrad Razavi, Zahra Najaf Arab, Maryam Khanahmadi, Amirreza Samanian, Saeideh Momtaz, Vasily N. Sukhorukov, Tannaz Jamialahmadi, Amir Hossein Abdolghafari, GEORGE BARRETOGEORGE BARRETO, Amirhossein Sahebkar

Inflammation in the nervous system is one of the key features of many neurodegenerative diseases. It is increasingly being identified as a critical pathophysiological primitive mechanism associated with chronic neurodegenerative diseases following traumatic brain injury (TBI). Phytochemicals have a wide range of clinical properties due to their antioxidant and anti-inflammatory effects. Currently, there are few drugs available for the treatment of neurodegenerative diseases other than symptomatic relief. Numerous studies have shown that plant-derived compounds, in particular polyphenols, protect against various neurodegenerative diseases and are safe for consumption. Polyphenols exert protective efects on TBI via restoration of nuclear factor kappa B (NF-κB), toll-like receptor-4 (TLR4), and Nod-like receptor family proteins (NLRPs) pathways. In addition, these phytochemicals and their derivatives upregulate the phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/ AKT) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, which have critical functions in modulating TBI symptoms. There is supporting evidence that medicinal plants and phytochemicals are protective in different TBI models, though future clinical trials are needed to clarify the precise mechanisms and functions of different polyphenolic compounds in TBI.

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Publication

Molecular Neurobiology

Publisher

Springer

Other Funding information

IReL

Sustainable development goals

  • (3) Good Health and Well-being

Department or School

  • Biological Sciences

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