Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds
posted on 2018-04-26, 15:31authored byBasant K. Puri, Mary Egan, Fintan Wallis, Philip M. Jakeman
AIM
To investigate the repeatability of proton magnetic resonance
spectroscopy in the in vivo measurement of human
cerebral levels of choline-containing compounds (Cho).
METHODS
Two consecutive scans were carried out in six healthy
resting subjects at a magnetic field strength of 1.5
T. On each occasion, neurospectroscopy data were
collected from 64 voxels using the same 2D chemical
shift imaging (CSI) sequence. The data were analyzed
in the same way, using the same software, to obtain the
values for each voxel of the ratio of Cho to creatine. The
Wilcoxon related-samples signed-rank test, coefficient
of variation (CV), repeatability coefficient (RC), and
intraclass correlation coefficient (ICC) were used to
assess the repeatability.
RESULTS
The CV ranged from 2.75% to 33.99%, while theminimum RC was 5.68%. There was excellent reproducibility,
as judged by significant ICC values, in 26 voxels.
Just three voxels showed significant differences
according to the Wilcoxon related-samples signed-rank
test.
CONCLUSION
It is therefore concluded that when CSI multivoxel
proton neurospectroscopy is used to measure
cerebral choline-containing compounds at 1.5 T, the
reproducibility is highly acceptable.