University of Limerick
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Sorbitol-coated indomethacin and naproxen particles produced by  supercritical CO2-assisted spray drying

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journal contribution
posted on 2023-05-22, 09:38 authored by FIDEL MENDEZ CANELLASFIDEL MENDEZ CANELLAS, Robert Geertman, Lidia Tajber, Luis PadrelaLuis Padrela

Co-spraying active pharmaceutical ingredients (APIs) with excipients is a strategy to create excipient matrices  containing API particles to address formulation challenges such as the reconstitution of powders into homogeneous suspensions. In this work, indomethacin and naproxen were co-sprayed with/without sorbitol using supercritical CO2-assisted spray drying (SASD), followed by particle collection in a filter paper, and resuspension in  an aqueous excipient solution. SASD yielded particles in the range of 0.4–7.6 µm, naproxen crystalline Form 1  particles in an amorphous sorbitol matrix, and a partially crystalline indomethacin-sorbitol mixture. Most  naproxen-sorbitol mixtures successfully constituted homogenous microparticle suspensions where sorbitol matrix dissolved upon contact with water releasing naproxen particles, while indomethacin-sorbitol mixtures were  not reconstitutable and not studied further. The API-sorbitol interactions were studied in detail by thermal  analysis and COSMO-RS modelling. Overall, the work presented herein provides a better understanding of co-spraying of APIs with excipients for the formulation of reconstitutable dried micropartic 


IUTAM Symposium on Advanced Boundary Element Methods, Applications in Solid and Fluid Mechnaics, San Antonio, Texas, April 11-16, 1987

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The Journal of Supercritical Fluids 199, 105969



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