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Sorbitol-coated indomethacin and naproxen particles produced by  supercritical CO2-assisted spray drying

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journal contribution
posted on 2023-05-22, 09:38 authored by FIDEL MENDEZ CANELLASFIDEL MENDEZ CANELLAS, Robert Geertman, Lidia Tajber, Luis PadrelaLuis Padrela

Co-spraying active pharmaceutical ingredients (APIs) with excipients is a strategy to create excipient matrices  containing API particles to address formulation challenges such as the reconstitution of powders into homogeneous suspensions. In this work, indomethacin and naproxen were co-sprayed with/without sorbitol using supercritical CO2-assisted spray drying (SASD), followed by particle collection in a filter paper, and resuspension in  an aqueous excipient solution. SASD yielded particles in the range of 0.4–7.6 µm, naproxen crystalline Form 1  particles in an amorphous sorbitol matrix, and a partially crystalline indomethacin-sorbitol mixture. Most  naproxen-sorbitol mixtures successfully constituted homogenous microparticle suspensions where sorbitol matrix dissolved upon contact with water releasing naproxen particles, while indomethacin-sorbitol mixtures were  not reconstitutable and not studied further. The API-sorbitol interactions were studied in detail by thermal  analysis and COSMO-RS modelling. Overall, the work presented herein provides a better understanding of co-spraying of APIs with excipients for the formulation of reconstitutable dried micropartic 

Funding

IUTAM Symposium on Advanced Boundary Element Methods, Applications in Solid and Fluid Mechnaics, San Antonio, Texas, April 11-16, 1987

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History

Publication

The Journal of Supercritical Fluids 199, 105969

Publisher

Elsevier

Also affiliated with

  • Bernal Institute
  • Synthesis and Solid State Pharmaceutical Centre

Department or School

  • Chemical Sciences