posted on 2014-05-28, 09:28authored byP. Carroll, A. Hunter, D. Barry, E. Barrett, M. Loughnane, R. Donnelly, N. Murphy, Philip M. Jakeman
The study outlined here is part of an overall project, which aims to identify the optimum marker of bone resorption for
both healthy young males and post-menopausal, non-osteoporotic women, and is as yet ongoing1. The purpose of this
investigation was to quantify the components of variance in specific biochemical markers of bone turnover in healthy
males and post-menopausal women i.e. total (CVS), analytical (CVA), within-subject biological (CVI) and betweensubject
(CVG) variances. Using CVA and CVI for each individual, the individual critical difference (CDI) or least
significant change (P<0.05) was calculated as previously described2. This value represents the minimal difference
between two measurements of a biochemical marker that indicates a medically significant alteration of homeostasis (and
is not due to normal biological and/or analytical variability alone). Given the CD of these markers the viability of using
them in the assessment and/or monitoring of bone metabolism will be considered.
History
Publication
National Institute of Health Sciences Research Bulletin;1 (4), pp.44-45