University of Limerick
Browse
Jakeman_2002_components (2).pdf (24.7 kB)

The components of variance and the critical difference in specific markers of bone turnover in healthy adult males and postmenopausal women.

Download (24.7 kB)
journal contribution
posted on 2014-05-28, 09:28 authored by P. Carroll, A. Hunter, D. Barry, E. Barrett, M. Loughnane, R. Donnelly, N. Murphy, Philip M. Jakeman
The study outlined here is part of an overall project, which aims to identify the optimum marker of bone resorption for both healthy young males and post-menopausal, non-osteoporotic women, and is as yet ongoing1. The purpose of this investigation was to quantify the components of variance in specific biochemical markers of bone turnover in healthy males and post-menopausal women i.e. total (CVS), analytical (CVA), within-subject biological (CVI) and betweensubject (CVG) variances. Using CVA and CVI for each individual, the individual critical difference (CDI) or least significant change (P<0.05) was calculated as previously described2. This value represents the minimal difference between two measurements of a biochemical marker that indicates a medically significant alteration of homeostasis (and is not due to normal biological and/or analytical variability alone). Given the CD of these markers the viability of using them in the assessment and/or monitoring of bone metabolism will be considered.

History

Publication

National Institute of Health Sciences Research Bulletin;1 (4), pp.44-45

Publisher

National Institute of Health Sciences

Note

peer-reviewed

Other Funding information

EI

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC