University of Limerick
Browse
Flynn_2022_Impact.pdf (2.21 MB)

The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel

Download (2.21 MB)
journal contribution
posted on 2022-12-09, 09:28 authored by James FlynnJames Flynn, Mario Culebras, MAURICE COLLINSMAURICE COLLINS, Sarah P. Hudson

In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent  changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profle of an encapsulated bacteriocin, nisin A, are explored. As the degree of oxidation increases, the weight average  molecular mass of the dextran decreases, resulting in a reduction in elastic modulus of the gels made. Upon encapsulation  of the bacteriocin nisin into the gels, varying the dextran mass/oxidation level allowed the antimicrobial activity against  S. aureus to be controlled. Gels made with a higher molecular weight (less oxidised) dextran show a higher initial degree  of inhibition while those made with a lower molecular weight (more oxidised) dextran exhibit a more sustained inhibition.  Incorporating glycol chitosan into gels composed of dextran with higher masses signifcantly increased their storage modulus  and the gels’ initial degree of inhibition. 

Funding

Bio-availing of Antimicrobial Resources

Science Foundation Ireland

Find out more...

SSPC_Phase 2

Science Foundation Ireland

Find out more...

History

Publication

Drug Delivery and Translational Research

Publisher

Springer

Also affiliated with

  • Bernal Institute
  • Health Research Institute (HRI)

Department or School

  • Chemical Sciences
  • School of Engineering

Usage metrics

    University of Limerick

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC