Date
2020
Abstract
Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.
Supervisor
Description
peer-reviewed
Publisher
John Wiley & Sons, Inc.
Citation
Phytotherapy Research;34 (11), pp. 2911-2920
Collections
Biological Sciences
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Majeed_2020_Potential.pdf
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Keywords
curcuminoids, viral infection, pulmonary fibrosis, acute respiratory distress syndrome
ULRR Identifiers
https://researchrepository.ul.ie/handle/10344/10497
 https://doi.org/10.34961/6184
Funding code
Funding Information
Sustainable Development Goals
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/
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