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Regioselective partial hydrogenation and deuteration of tetracyclic (Hetero)aromatic systems using a simple heterogeneous catalyst
Date
2024
Abstract
The introduction of added ‘3-dimensionality’ through late-stage functionalisation of extended (hetero)aromatic systems is a powerful synthetic approach. The abundance of starting materials and cross-coupling methodologies to access the precursors allows for highly diverse products. Subsequent selective partial reduction can alter the core structure in a manner of interest to medicinal chemists. Herein, we describe the precise, partial reduction of multicyclic heteroaromatic systems using a simple heterogeneous catalyst. The approach can be extended to introduce deuterium (again at late-stage). Excellent yields can be obtained using simple reaction conditions.
Supervisor
Description
Publisher
Wiley and Sons Ltd.,
Citation
Chemistry, 2024, 30, e202400102