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Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.
O'Connell, Karen; Kelly, Siobhan B.; Kinsella, Katie; Jordan, Sinead; Kenny, Orla; Murphy, David; Heffernan, Eric; O'Laoide, Risteard; O'Shea, Donal; McKenna, Carmel; Cassidy, Lorraine; Fletcher, Jean; Walsh, Cathal Dominic; Brady, Jennifer J.; McGuigan, Christopher; Tubridy, Niall; Hutchinson, Michael
Date
2013
Abstract
There is increasing evidence linking vitamin D deficiency to both susceptibility to, and severity of, multiple sclerosis (MS). Patients with the clinically isolated syndrome represent the initial presentation of a demyelinating disorder, and those with asymptomatic lesions on magnetic resonance imaging (MRI) are at risk of progression to clinically definite MS. The aims of this study are to examine the immunologic effects of vitamin D in both healthy individuals and in patients with clinically isolated syndrome, and in the latter group the effects on disease progression assessed by MRI and clinical measures.
Supervisor
Description
peer-reviewed
Publisher
BioMed Central Ltd.
Citation
Trials;14: 272
Collections
Files
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Walsh_2013_dose.pdf
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