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Conservation of mercury resistance determinants amongst ICE-like mobile bacterial genetic elements: comparative analysis and dissection of function

Date
2018
Abstract
Enterobacterial Integrative Conjugative Elements (ICEs) are now detected regularly as carriers of drug resistance and adaptive functions in clinical, animal and environmental bacterial isolates. The elements, which appear as conjugative phage/ plasmid- like hybrids, have a core genetic structure comprising of integrative, regulatory and conjugative transfer functions. Several integrative hotspots within the elements have been characterised where genes from host organisms or transposonassociated elements integrate resulting in evolution of the ICE element itself. One such ICE integrating hotspot, originally characterised in the ICER391, contains a mercury resistance determinant. Bioinformatic analysis of several ICE elements has revealed the conservation of similar mercury resistance determinants amongst ICE elements from a wide geographical origin. Here we compare and characterise this ICER391 mercury resistant determinant and use molecular and bioinformatic analysis to delineate its structure, possible origin and function
Supervisor
Description
peer-reviewed
Publisher
Formatex
Citation
Understanding microbial pathogens: current knowledge and educational ideas on antimicrobial research, Enrique Torres-Hergueta and A. Méndez-Vilas, (eds) ;pp, 121-126
Collections
Bernal Institute
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121-126.pdf
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Keywords
Mercury resistance
ULRR Identifiers
https://researchrepository.ul.ie/handle/10344/7348
 https://doi.org/10.34961/4693
Funding code
Funding Information
Sustainable Development Goals
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Type
Book chapter
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/
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