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Biological evaluation of nano hydroxyapatite zirconia (HA-ZrO2) composites for load bearing applications.
Date
2012
Abstract
The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatitezirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings and novel microwave sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favourable response from rat osteosarcoma cells (ROS). In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be a due to the incorporation of Sr and the formation of a surface apatite layer.
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Description
peer-reviewed
Publisher
SAGE Publications Ltd.
Citation
Journal of Biomaterials Applications;27(3), pp. 291-298
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Funding Information
Enterprise Ireland (EI)