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In vitro antioxidant and immunomodulatory activity of transglutaminase-treated sodium caseinate hydrolysates
Date
2016
Abstract
Sodium caseinate (NaCN) was incubated prior to and after hydrolysis with a microbial transglutaminase (TGase) and hydrolysed with Prolyve 1000. The resultant hydrolysates were tested for their immunomodulatory and antioxidant activity. TGase-treated hydrolysates significantly reduced (p 0.05) differences were found between the TGase-treated and non-TGase-treated samples. In the presence of hydrogen peroxide, the non-TGase-treated sample exhibited the highest DNA protective effect in U937 cells. These findings suggest that NaCN derived hydrolysates with and without treatment with TGase may exert specific antioxidant, genoprotective and anti-inflammatory effects. (C) 2016 Elsevier Ltd. All rights reserved.
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Description
peer-reviewed
Publisher
Elsevier
Citation
International Dairy Journal;63, pp. 107-114
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Funding Information
Department of Agriculture, Food and the Marine