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Scaffold fabrication technologies and structure/function properties in bone tissue engineering
Date
2021
Abstract
Bone tissue engineering (BTE) is a rapidly growing field aiming to create a bio functional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided herein. Different types of biomaterials ranging from inorganic biomaterials to natural and synthetic polymers and related composites for scaffold processing are presented. Emergent scaffolding techniques such as electrospinning, freeze-drying, bioprinting, and decellularization are also discussed. Strategies to improve vascularization potential and immunomodulation, which is considered a grand challenge in BTE scaffolding, are also presented.
Supervisor
Description
peer-reviewed
Publisher
John Wiley & Sons, Inc.
Citation
Advanced Functional Materials;2010609
Files
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Collins_2021_Scaffold.pdf
Adobe PDF, 5.58 MB
Keywords
Funding code
Funding Information
Portuguese Foundation for Science and Technology
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/