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The psychological impact of Stevens- Johnson syndrome and toxic epidermal necrolysis on patients' lives: a critically appraised topic
Date
2019
Abstract
A 65‐year‐old man presented with a 12‐h history of deteriorating rash. Two weeks previously he had completed a course of neoadjuvant chemotherapy for ductal carcinoma of the breast. On examination there were bullae, widespread atypical targetoid lesions and 15% epidermal detachment. There was no mucosal involvement on presentation, but subsequently it did evolve. Skin biopsy showed subepidermal blistering with epidermal necrosis. This confirmed our clinical diagnosis of overlap Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). On transfer to intensive care he was anxious and fearful. Management question What are the psychological impacts of SJS/TEN on this man's life? Background SJS and TEN have devastating outcomes for those affected. Objectives To conduct a Critically Appraised Topic to (i) analyse existing research related to the psychological impact of SJS and TEN and (ii) apply the results to the clinical scenario. Methods Seven electronic databases were searched for publications focusing on the psychological impact of SJS/TEN on adults over 18 years of age. Results Six studies met the inclusion criteria. Healthcare practitioners’ (HCPs’) lack of information around the disorder was highlighted. Patients experienced undue stress and fear. Some patients had symptoms aligned to post‐traumatic stress disorder (PTSD), anxiety and depression. Discussion and recommendation The evidence suggests that SJS and TEN impact psychologically on patients’ lives. Education of HCPs, to address their lack of awareness and information on SJS/TEN, should facilitate their capacity to provide information and support to patients, thereby reducing patient anxiety. On discharge, a follow‐up appointment with relevant HCPs to reduce the possibility of PTSD occurring should be considered.
Supervisor
Description
peer-reviewed
Publisher
John Wiley & Sons, Inc.
Citation
British Journal of Dermatology; 183 (3),pp. 452-461
Keywords
Funding code
Funding Information
This research was funded by the Health ResearchInstitute, University of Limerick, Ireland
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/