Date
2024
Abstract
Short peptides are attractive building blocks for the fabrication of self-assembled materials with significant biological, chemical, and physical properties. The microscopic and macroscopic properties of assemblies are usually closely related to the dimensionality of formed hydrogen bond networks. Here, two completely different supramolecular architectures connected by distinct hydrogen bond networks were obtained by simply adding a hydroxyl group to switch from cyclo-tryptophan-alanine (cyclo-WA) to cyclo-tryptophan-serine (cyclo-WS). While hydroxyl-bearing cyclo-WS molecules provided an additional hydrogen bond donor that links to adjacent molecules, forming a rigid three-dimensional network, cyclo-WA arranged into a water-mediated zipper-like structure with a softer two-dimensional layer template. This subtle alteration resulted in a 14-fold enhancement of Young’s modulus values in cyclo-WS compared to cyclo-WA. Both cyclo-dipeptides exhibit biocompatibility, high fluorescence, and piezoelectricity. The demonstrated role of dimensionality of hydrogen bond networks opens new avenues for rational design of materials with precise morphologies and customizable properties for bioelectronic applications.
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Description
Publisher
American Chemical Society
Citation
ACS Materials Letters,. 2024, 6 (8), pp. 3824–3833
Collections
Physics
Bernal Institute
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Keywords
crystal structure, crystals, noncovalent interactions, supramolecular chemistry, supramolecular structures and assemblies
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.26561434
 https://researchrepository.ul.ie/handle/10344/13683
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Funding Information
This work was supported in part by the Ministry of Science and Technology of Israel project (grant no. 3-18130) within the China-Israel Cooperative Scientific Research (2022YFE0100800), the ISF- Israel Science Foundation by Grant no. 3246/23, Twin2pipsa - Twinning for excellence in biophysics of protein interactions and self-assembly grant (101079147), Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems (GZKF-202224) and International Partnership Program of the Chinese Academy of Sciences (039GJHZ2023058FN). D.T. and P.A.C. acknowledge support from Science Foundation Ireland (SFI) under award number 12/RC/2275_P2 (SSPC) and supercomputing resources at the SFI/Higher Education Authority Irish Center for High-End Computing (ICHEC).
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Article
Rights
https://creativecommons.org/licenses/by-nc-sa/4.0/
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