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MRI guided magneto-chemotherapy with high-magnetic-moment iron oxide nanoparticles for cancer theranostics
Date
2020
Abstract
Elevating and monitoring the temperature of tumors using magnetic nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next-generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high-magnetic-moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, we developed high-magnetic-moment iron oxide (Fe3O4) nanoparticles (NPs) using base diisopropylamine (DIPA), which plays a dual role as reducing agent and surface stabilizer. Spherical NPs with ∼12 nm size and a high magnetization value of about 92 emu g–1 at room temperature are obtained by this unique method. A high specific absorption rate value of ∼717 wg–1 was obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm–1 and frequency of 267 kHz, which is attributed to the high magnetization value. The magneto-polymeric micelle structure is formed by using Pluronic F127, and anticancer drug doxorubicin is conjugated in the micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7) cells with an overall ∼96% killing of cancer cells attained in 30 min of magneto-chmeotherapy.
Supervisor
Description
peer-reviewed
Publisher
American Chemical Society
Citation
ACS Applied Bio Materials;3 (4), pp. 2305-2313
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Tofail_2020_MRI.pdf
Adobe PDF, 1.54 MB
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Funding Information
European Research Council (ERC), Irish Research Council (IRC)