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Mesoscale clusters in the crystallisation of organic molecules

Date
2023
Abstract
Abstract: The early stages of the molecular self-assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X-ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large-molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.
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Description
Publisher
Wiley-VCH GmbH
Citation
Angewandte Chemie International, e202312100
Collections
Chemical Sciences
Bernal Institute
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Barua_2023_Mesoscale.pdf
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Keywords
mesoscale clusters, nanoscale characterisation methods, nonclassical nucleation, organic compounds, pre-nucleation, Chemical sciences
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.25011203
 https://researchrepository.ul.ie/handle/10344/13261
Funding code
Funding Information
Irish Research Council (IRC) (GOIPD/2021/27) Swedish Research Council grant number 2019–5059) IReL
Sustainable Development Goals
(9) Industry, Innovation and Infrastructure
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/4.0/
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