Date
2018
Abstract
Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidantâ MitoQâ was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes.
Supervisor
Description
peer-reviewed
Publisher
MDPI
Citation
Materials;11: 569
Collections
Bernal Institute
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Collins_2018_MitoQ.pdf
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Keywords
mitochondrially-targeted antioxidant, skin wounds, hyaluronan, chitosan
ULRR Identifiers
https://hdl.handle.net/10344/6833
 https://doi.org/10.34961/4666
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Funding Information
Sustainable Development Goals
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