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Solid solution polymorphs afford two high-soluble co-drug forms of tolbutamide and chlorpropamide

Date
2023
Abstract
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.
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Description
Publisher
Royal Society of Chemistry
Citation
Chemical Communications, 2023, (59), pp. 14321-14324
Collections
Chemical Sciences
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Spoletti_2023_Solid.pdf
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Keywords
tolbutamide, chlorpropamide, mixed crystals, pharmaceutical therapies, Chemical sciences
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.24796266
 https://researchrepository.ul.ie/handle/10344/13168
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Sustainable Development Goals
(4) Quality Education, (3) Good Health and Well-Being
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/4.0/
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