Loading...
Serum uric acid and mortality thresholds among men and women in the Irish health system: A cohort study
Date
2021
Abstract
Background: Elevation of serum uric acid (SUA) is associated with increased mortality; however, controversy exists regarding the nature of the relationship and differences between men and women. We explored relationships of SUA levels with all-cause mortality in a large cohort of patients within the Irish health system. Methods: A retrospective cohort study of 26,525 participants was conducted using data from the National Kidney Disease Surveillance System. SUA was modelled in increments of 59.48 µmol/L (1 mg/dL), Cox’s proportional hazards model estimated hazard ratios (HRs) and 95% Confidence Intervals (CI), median lifetimes were also computed separately for men and women. Mortality patterns were further explored using penalised splines. Results: There were 1,288 (4.9%) deaths over a median follow-up of 5.1 years. In men, the risk of mortality was greatest for the lowest ( 535 µmol/L) categories [HR 2.35 (1.65–3.14) and HR 2.52 (1.87–3.29) respectively]; the corresponding median lifetimes for men were reduced by 9.5 and 11.7 years respectively compared to the referent. In women, mortality risks were elevated for SUA >416 mol/L [HR 1.69 (1.13–2.47) and beyond; the corresponding median lifetime for women were reduced by 5.9 years compared to the referent. Spline analysis revealed a U-shaped association between SUA and mortality in men, while for women, the pattern of association was J-shaped. Conclusion: Mortality patterns attributed to SUA differ between men and women. Optimal survival was associated with SUA concentrations of 304–454 µmol/L for men and < 409 µmol/L for women.
Supervisor
Description
peer-reviewed
Publisher
Elsevier
Citation
Journal of Internal Medicine;84, pp. 64-55
Files
Loading...
Browne_2021_Serum.pdf
Adobe PDF, 1.74 MB
Keywords
Funding code
Funding Information
Health Research Board (HRB), Midwest Research and Education Foundation, Menarini International Operations Luxemburg, Irish Research Council (IRC)
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/