Date
2014
Abstract
This study investigates the ability of milk protein-derived peptides to specifically activate the serotonin 2C (5-HT2C) receptor, a key receptor in central regulation of food intake. A dose dependent 5-HT2C receptor activation by the 1 kDa ultrafiltration permeates of a sodium caseinate (NaCNH-1 kDa permeate) and a whey protein hydrolysate (WPH-1 kDa permeate) was demonstrated using an intracellular calcium mobilization assay in human embryonic kidney (Hek) cells expressing the 5-HT2C receptor. Both samples activated the 5-HT2C but not the 5-HT2A and 5-HT2B receptors. NaCNH-1 kDa permeate significantly (p < 0.01) reduced cumulative food intake when administered to male mice (C57Bl/6) by intraperitoneal injection at 500 mg kg-1 body weight. In contrast, no effect of WPH-1 kDa permeate could be seen on food intake in vivo. These results demonstrate the promising appetite-suppressing potential of NaCN-derived peptides, targeting the 5-HT2C receptor.
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Description
peer-reviewed
Publisher
Elsevier
Citation
International Dairy Journal;38, 1, pp. 55-64
Collections
Biological Sciences
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Schellekens_et_al._IDJ_2014.pdf
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Keywords
5-HT2C serotonin receptors, amino-acids profiles, food intake, alpha-lactalbumin
ULRR Identifiers
https://hdl.handle.net/10344/5711
 https://doi.org/10.34961/5704
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Funding Information
Enterprise Ireland (EI)
Sustainable Development Goals
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