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A preliminary study examining the binding capacity of akkermansia muciniphila and desulfovibrio spp., to colonic mucin in health and ulcerative colitis

Date
2015
Abstract
Akkermansia muciniphila and Desulfovibrio spp. are commensal microbes colonising the mucus gel layer of the colon. Both species have the capacity to utilise colonic mucin as a substrate. A. muciniphila degrades colonic mucin, while Desulfovibrio spp. metabolise the sulfate moiety of sulfated mucins. Altered abundances of these microorganisms have been reported in ulcerative colitis (UC). However their capacity to bind to human colonic mucin, and whether this binding capacity is affected by changes in mucin associated with UC, remain to be defined.
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Description
peer-reviewed
Publisher
Public Library of Science
Citation
PloS ONE;10 (10), e0135280
Collections
School of Medicine
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Coffey_2015_health.pdf
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Keywords
bacteria, Akkermansia muciniphila, Desulfovibrio spp
ULRR Identifiers
https://researchrepository.ul.ie/handle/10344/4991
 https://doi.org/10.34961/7281
Funding code
Funding Information
Sustainable Development Goals
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/
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