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Remote history of VTE is associated with severe COVID-19 in middle and older age: UK biobank cohort study
Anderson, Jana J.; Ho, Frederick K.; Niedzwiedz, Claire L.; Katikireddi, Srinivasa Vittal; Celis-Morales, Carlos A.; Iliodromiti, Stamatina; Welsh, Paul; Pellicori, Pierpaolo; Demou, Evangelia; Hastie, Claire E.; Lyall, Donald M.; Gray, Stuart R.; Forbes, John F.; Gill, Jason M.R.; Mackay, Daniel F.; Berry, Colin; Cleland, John G.F.; Sattar, Naveed; Pell, Jill P.
Date
2021
Abstract
Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19-related hospital admissions, and COVID-19 deaths. The risk of COVID-19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates.
Supervisor
Description
peer-reviewed
Publisher
John Wiley & Sons, Inc.
Citation
Journal of Thrombosis and Haemostasis;pp. 1–6
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Forbes_2021_Remote.pdf
Adobe PDF, 413.77 KB
Keywords
Funding code
Funding Information
Scottish Government, Medical Research Council, British Heart Foundation
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/
