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Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety

Date
2017
Abstract
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
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Description
peer-reviewed
Publisher
SAGE Publications Ltd.
Citation
Breast Cancer: Basic and Clinical Research;11, pp. 1-18
Collections
School of Medicine
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Lowery_2017_Adipose.pdf
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Keywords
breast reconstruction, mastectomy, adipose-derived stem cells, tissue engineering, adipose tissue engineering, breast cancer
ULRR Identifiers
https://hdl.handle.net/10344/6059
 https://doi.org/10.34961/6569
Funding code
Funding Information
Sustainable Development Goals
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/
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