Date
2011
Abstract
PURPOSE. To design a contact lens to treat and prevent fungal ocular infections.METHODS. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37 degrees C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.RESULTS. Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.CONCLUSIONS. An econazole-eluting contact lens could be used as a treatment for fungal ocular infections. (Invest Ophthalmol Vis Sci. 2011;52:6286-6291) DOI:10.1167/iovs.10-6935
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Description
peer-reviewed
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Investigative Ophthalmology and Visual Science;52 (9), pp. 6286-6291
Collections
Chemical Sciences
Bernal Institute
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Keywords
fungal keratitis, drug-delivery, management, fusarium, susceptibility, ganciclovir, temperature, outbreak
ULRR Identifiers
https://hdl.handle.net/10344/5020
 https://doi.org/10.34961/4605
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Funding Information
Sustainable Development Goals
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