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Publication

Engineering strategies and therapeutic applications of synthetic Notch (synNotch) receptors in cancer therapeutics

Date
2026-03-01
Abstract
Synthetic Notch (synNotch) receptors have been developed as a novel approach to cell-based immunotherapy and will provide programmable, specific cancer treat-ments. Unlike existing fixed chimeric antigen receptor (CAR)-T cell therapies, synNotch receptors are a combi-nation of modular domains, such as extracellular, transmembrane, and intracellular domains, for influencing gene expression depending on the present ligand. Through Boolean logic-based cellular decisions, synNotch receptors allow for a higher degree of precision and a lower degree of off-target effects.
Supervisor
Description
Publisher
Elsevier
Citation
Drug Discovery Today 31(2), 104619
Collections
Physics
Bernal Institute
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Thorat_2026_Engineering.pdf
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Keywords
synNotch receptors, logic-gated CAR-T, programmable immunotherapy, syntheticbiology, cancer therapeutics
ULRR Identifiers
https://hdl.handle.net/10344/31627
 https://doi.org/10.34961/19266
Funding code
Funding Information
Sustainable Development Goals
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License
Attribution-NonCommercial-ShareAlike 4.0 International
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