Loading...
Targeting protein kinase C downstream of growth factor and adhesion signalling.
Date
2015
Abstract
The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment.
Supervisor
Description
peer-reviewed
Publisher
MDPI
Citation
Cancers; 7, pp. 1271-1291
Files
ULRR Identifiers
Funding code
Funding Information
Irish Cancer Society, Science Foundation Ireland (SFI)