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Postural control deficits in people with multiple sclerosis: A systematic review and meta-analysis
Date
2018
Abstract
Background Multiple sclerosis (MS) is a neurological condition that can affect the postural stability of the individual and predispose falls in this population. Methods A systematic literature search identified case-control studies investigating differences in postural control across a diversity of task conditions, with the exception of gait, between people with MS and healthy controls. Meta-analysis was conducted where a variable was presented by four or more studies. Results Forty-three studies of people with a mean Expanded Disability Status Scale (EDSS) of 1.0 to 6.0 were included. Seven conditions of assessment and 105 individual measurement variables relating to postural control were included. Quiet stance was the only condition (11 studies) possessing sufficient data to contribute to meta-analysis in terms of centre of pressure path length (SMD = 1.04, 95% CI {0.86–1.22}, p < 0.001), medio-lateral velocity (SMD = 1.35, 95% CI {0.77–1.92}, p < 0.001) and 95% confidence ellipse (SMD = 0.83 95% CI {0.59–1.08}, p < 0.001). Results indicate that regardless of task complexity or sensory condition, people with MS display considerable deficits in postural control in comparison to healthy controls. Conclusions The large number of variables and lack of standardisation of reporting makes data synthesis challenging, however, people with MS display considerable deficits in postural control compared to healthy controls regardless of task condition or complexity
Supervisor
Description
peer-reviewed
The full text of this article will not be available in ULIR until the embargo expires on the 19/2/2019
Publisher
Elsevier
Citation
Gait and Posture;61, pp. 445-452
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Files
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Comber_2018_Postural.pdf
Adobe PDF, 462.9 KB