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Intracerebroventricular administration of amyloid beta-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat
Date
2008
Abstract
Extensive evidence supports an important role for soluble oligomers of the amyloid. beta-protein (A beta) in Alzheimer's Disease pathogenesis. In the present study we combined intracerebroventricular (icv) injections with brain microdialysis technology in the fully conscious rat to assess the effects of icv administered SDS-stable low-n A beta oligomers ( principally dimers and trimers) on excitatory and inhibitory amino acid transmission in the ipsilateral dorsal hippocampus. Microdialysis was employed to assess the effect of icv administration of A beta monomers and A beta oligomers on dialysate glutamate, aspartate and GABA levels in the dorsal hippocampus. Administration of A beta oligomers was associated with a + 183% increase ( p
Supervisor
Description
peer-reviewed
Publisher
MDPI
Citation
Sensors;8, pp. 7428-7437
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Files
Funding code
Funding Information
NIH, Wellcome Trust, Science Foundation Ireland (SFI), Higher Education Authority (HEA)
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/